Deal with It

HYPOCHONDRIAC: What starts out as simple exercises in staying healthy quickly turns into a series of obsessive procedures, as our contestant finds creative ways of keeping the germs at bay. Co-host: Howie Mandel. BEST MEDICINE:

ART CLASS: Beauty is only skin deep, and this contestant experiences that firsthand, after requesting that a model in an art class get nude for the sake of her sculpture.

MEMORIAL: A devastated friend questions the morality of our contestant, after she's instructed to deface a deceased man's portrait during a memorial service. Co-host: Iliza Shlesinger.

CONVERTED: A contestant has converted to a new-age religion, and must put their rituals on display by anointing their friend with a blessing of barbeque sauce.

WITNESS RELOCATION: A contestant is instructed to disguise her identity, after a run-in with a couple of mobsters reveals a clue about her mysterious past.

BROMANCE: Things get awkward when our contestant is instructed to breakup with his BFF, then introduce him to the new one. Co-host: Arsenio Hall. TV HOST: After welcoming his fellow diners, this contestant is told to turn the restaurant into his own late-night talk show. Co-host: Alex Mandel.

DOUBLE DATE: When our contestant reveals to her sister that she's set them both up on a blind date with two guys from the Internet, neither of their dates comes anywhere close to being "prince charming." Co-host: Chuey Martinez.

CUTESY PIE: After whispering sweet nothings to his friend, our contestant is instructed to take their relationship to the next level, by locking lips with him in an unusual way. Co-host: Howie Mandel.

ESCORT: After dropping the news that she's an escort for older men, our contestant and her friend must deal with a creepy client, who wants to take them out for a night on the town. Co-host: Kelly Osbourne.

TIGER URINE: After divulging her digestive issues, this contestant reveals her questionable new dietary supplement that leaves a bad taste in her friend's mouth. Co-host: David Koechner. YOUR BIGGEST FAN: A superfan's flattery goes a little too far, when our contestant is tasked with convincing her rock star boyfriend to let the creepy stranger stay the night at his place. Co-host: Alex Mandel.

BUYER'S REMORSE: When this contestant is tasked with signing off on a number of bizarre online purchases, she finds herself dealing with someone else's dirty laundry. Co-host: Tom Green.

LAUGHS: This contestant takes the saying "laughter is the best medicine" a little too seriously, after getting the giggles at his waiter's misfortunes. THE ACCIDENT: H20 is what's on the menu during this prank that escalates when our contestant has an accident in his pants.

Hosted by Theo Von and executive produced by Howie Mandel, the second season of Deal With It features a jam-packed roster of guest celebrities and comedians helping pull over-the-top pranks on the unsuspecting public.

FOOTBALL: A contestant has football on the brain and decides to kick off the new season while her friend watches from the sideline. Co-host: Bobby Lee.CHAMPAGNE PROBLEMS: After faking a foot injury, our contestant enlists the help of their friend, and then offers a thank you with a face full of foot. Co-host: Ross Mathews.

WINE TASTING: After our contestant hijacks a wine tasting seminar, and chugs from a $3,000 bottle of wine, her friend might just want a drink of her own. Co-host: Jeannie Mai. THE WILL: A contestant's daughter is having the worst day of her life, after her father informs her she's out of his will. The icing on the cake? He's letting his sexy new attorney handle the money. Co-host: Jerry O'Connell.

STAKEOUT: After witnessing our contestant confiscate a stranger's personal belongings, this friend is doing all he can to prevent the paranoia from resulting in someone wearing handcuffs. Co-host: Kym Whitley. BLOWOUT: When our contestant notices an elderly lady celebrating her birthday, he decides to join in the fun, by blowing out the candles in an unusual way. Co-host: Josh Wolf.

DOCTOR'S WAITING ROOM: After irritating several patients in a doctor's waiting room, a contestant has to deal with her husband's rising blood pressure. Co-host: Alex Mandel. HIGH SCHOOL SWEETHEART: A contestant takes the concept of mid-life crisis to a whole new level, as she is tasked with introducing her friend to Kevin, her high school sweetheart. Co-host: Andrew Bachelor "King Bach".

TURKEY DANCE: After demanding some turkey, then stealing two of the raw birds from a nearby counter, a contestant has his hands full trying to explain himself to his irritated wife.

SPEED DATING (HALLMARK): After stumbling into a speed dating session, a contestant's girlfriend is in for the worst date of her life when an attractive woman wants to "lock-in" with her man.

NARCOLEPTIC: A contestant can't stay awake, and when slapping herself and splashing water on her face doesn't work, she has to get her friend to give her a rude awakening. Co-host: Chuey Martinez. YOGA CLASS (PRINGLES): A contestant is tasked with disrupting a yoga class by demonstrating his own obnoxious custom stretches. Co-host: Josh Meyers.

AWARDS LUNCH (REDD'S APPLE ALE): When her lunch is interrupted by a substitute teacher's appreciation ceremony, our contestant decides to show her support with a rousing cheer. Cohost: Melissa Peterman.

ANHERITANCE: As if revealing he's a gigolo for elderly women isn't difficult enough, this contestant has his hands full when his favorite client shows up and proposes an item to cross of her bucket list. LIFESTYLE CHANGE: After introducing his wife to some people he met on an alternative lifestyle website that specializes in cuddling parties, the last thing this contestant's wife wants is a hug.